Results : When RTX is not used, total annual medical cost is V16,555 per patient, V13,206 of which are dedicated to drug acquisition. When RTX is the only treatment in use, these costs decrease respectively to V11,444 and V7469. Total savings per patient and per year is V5000. Over 4 years, total savings for the targeted population reach V118 M. In the sensitivity analysis, the difference between H2 and H2-coeff 2 (20%) reaches V5,400,000 in total direct costs during the first year of simulation. This difference decreases along the period, to reach V2,400,000 the fourth year of simulation, and is due to the fact that rituximab acquisition costs are independent from the treatment line.
Conclusion : If TNFa inhibitors were the only treatment available, the annual global cost of treatment would be V16,555 per patient versus V11,444 for patients treated exclusively with rituximab. RTX is expected to produce important savings (-31%) if used after failure of one or more TNFa therapies. This is mainly due to its lower drug acquisition cost. These savings could increase with the development of rituximab in earlier stages of treatment.